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Abstract #0465

Quantitative Susceptibility Mapping of Human Brain by Inverting Local Magnetic Fields Measured at Multiple Small Angles

Tian Liu1,2, Pascal Spincemaille2, Ludovic de Rochefort2, Martin Prince2, Yi Wang1,2

1Biomedical Engineering, Cornell University, Ithaca, NY, USA; 2Radiology, Weill Cornell Medical College, New York, NY, USA

Quantitative susceptibility mapping of the brain would be valuable for assessing iron or calcium deposits associated with neurodegenerative and ischemic diseases, and for quantifying deoxygenated venous blood in fMRI. In this study, Calculation of Susceptibility through Multiple Orientation Sampling (COSMOS) was adapted to quantitatively map susceptibility of the cerebral venous blood. Veins were well-distinguished from the surrounding tissues and oxygen saturation level was assessed.