Abstract #0514

Transcortical BOLD Impulse Response Functions: Implications for Layer-Specific CMRO2 Calculation

Peter Herman^1,2, Basavaraju G. Sanganahalli¹, Hal Blumenfeld^3,4, Fahmeed Hyder^1,5

¹Diagnostic Radiology, Yale University, New Haven, CT, USA; ²Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest, Hungary; ³Neurology, Yale University, New Haven, CT, USA; ⁴Neurobiology, Yale University, New Haven, CT, USA; ⁵Biomedical Engineering, Yale University, New Haven, CT, USA

Oxidative neuroenergetics with calibrated fMRI has become a popular technique. Measurements of BOLD, CBV, CBF and/or neural activity are needed to calculate CMR_O2. Transcortical selection of signals can be an important factor as these parameters may vary across cortical layers. We calculated transfer functions in three cortical layers to explore transcortical differences in BOLD and LFP signals. The amplitude of the BOLD and LFP signals decreases toward the deeper layers, but the normalized signals show very high correlation between layers. The transfer function analysis revealed, while the upper and middle layers interchangeable, the lower layer is needed for calibration separately.