Meeting Banner
Abstract #0514

Transcortical BOLD Impulse Response Functions: Implications for Layer-Specific CMRO2 Calculation

Peter Herman1,2, Basavaraju G. Sanganahalli1, Hal Blumenfeld3,4, Fahmeed Hyder1,5

1Diagnostic Radiology, Yale University, New Haven, CT, USA; 2Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest, Hungary; 3Neurology, Yale University, New Haven, CT, USA; 4Neurobiology, Yale University, New Haven, CT, USA; 5Biomedical Engineering, Yale University, New Haven, CT, USA

Oxidative neuroenergetics with calibrated fMRI has become a popular technique. Measurements of BOLD, CBV, CBF and/or neural activity are needed to calculate CMRO2. Transcortical selection of signals can be an important factor as these parameters may vary across cortical layers. We calculated transfer functions in three cortical layers to explore transcortical differences in BOLD and LFP signals. The amplitude of the BOLD and LFP signals decreases toward the deeper layers, but the normalized signals show very high correlation between layers. The transfer function analysis revealed, while the upper and middle layers interchangeable, the lower layer is needed for calibration separately.