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Abstract #0530

Liver Tissue Repair in a Mouse Model of Toxicant-Induced Liver Injury Is Associated with Increased Hepatic Energy Metabolism: a Multinuclear Magnetic Resonance Study

Sven Gottschalk1, Tom S. Chan1, Valrie-Ann Raymond1, Dieter Leibfritz2, Claudia Zwingmann1,2, Marc Bilodeau1

1Dpartement de sciences biomdicales, Universit de Montral, Montral, Qubec, Canada; 2Department of Organic Chemistry, University of Bremen, Bremen, Germany

Due to its ability regenerate, the liver is an ideal model for studying tissue repair mechanisms. Only little is known about the repair-associated changes in cellular metabolic pathways. Energy-intensive repair processes should be reflected in alterations in energy metabolism. An in vivo liver-injury model was used to generate an onset of liver tissue-repair. We assessed the extent of liver-injury and NMR-spectroscopy was used to characterize changes in energy metabolism and metabolites. Our results showed that induction of liver-regeneration was consistent with an up-regulation of the cells overall energy metabolism and a higher demand for TCA-cycle intermediates (eg. for amino-acids synthesis).