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Abstract #0556

Effects of a 3-Month Training Program on Muscular Lipid Metabolism and Physical Health in Sedentary Non-Insulin-Dependant Diabetes Mellitus Patients

Michael Ith1, Monika Mattes-Schaub1, Roland Kreis1, Kim-Anne L2, Luc Tappy2, Jean-Paul Schmid3, Emanuel Christ4, Chris Boesch1

1Department Clinical Research, University Bern, Bern, Switzerland; 2Physiology Department, University Lausanne, Lausanne, Switzerland; 3Cardiology Department, University Bern, Bern, Switzerland; 4Diabetology Department, University Bern, Bern, Switzerland

For patients with impaired insulin sensitivity there is a clear consensus that weight loss improves their metabolic state, however, the effect of increased physical activity is less clear. This study therefore aimed to investigate the effects of a 3-month structured training program on physical performance, clinical parameters as well as levels and utilization of intramyocellular lipids (IMCL) in patients with non-insulin dependent diabetes mellitus type 2. The presented results will demonstrate a significant improvement of metabolic state and physical performance together with reduced levels of IMCL thereby approaching values of a simultaneously investigated control group.