Abstract #0556

Effects of a 3-Month Training Program on Muscular Lipid Metabolism and Physical Health in Sedentary Non-Insulin-Dependant Diabetes Mellitus Patients

Michael Ith¹, Monika Mattes-Schaub¹, Roland Kreis¹, Kim-Anne L², Luc Tappy², Jean-Paul Schmid³, Emanuel Christ⁴, Chris Boesch¹

¹Department Clinical Research, University Bern, Bern, Switzerland; ²Physiology Department, University Lausanne, Lausanne, Switzerland; ³Cardiology Department, University Bern, Bern, Switzerland; ⁴Diabetology Department, University Bern, Bern, Switzerland

For patients with impaired insulin sensitivity there is a clear consensus that weight loss improves their metabolic state, however, the effect of increased physical activity is less clear. This study therefore aimed to investigate the effects of a 3-month structured training program on physical performance, clinical parameters as well as levels and utilization of intramyocellular lipids (IMCL) in patients with non-insulin dependent diabetes mellitus type 2. The presented results will demonstrate a significant improvement of metabolic state and physical performance together with reduced levels of IMCL thereby approaching values of a simultaneously investigated control group.