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Abstract #0585

The Association Between Choline Concentration Measured by 1H MR Spectroscopy with Clinical Characteristics and Biomarkers of Breast Cancer

Hui Liu1, Jeon-Hor Chen1,2, Hyeon-Man Baek1, Ke Nie1, Hon J. Yu1, Orhan Nalcioglu1, Min-Ying Lydia Su1

1Tu & Yuen Center for Functional Onco-Imaging, University of California, Irvine, CA, USA; 2Department of Radiology, China Medical University, Taichung, Taiwan

We investigated the association between tCho measured by single-voxel MRS (using the internal reference method) and other clinical characteristics in different breast lesions. A total of 63 patients were included. A higher choline concentration was significantly correlated with younger age (p<0.05), and was associated with DCE washout pattern (higher angiogenesis), higher tumor grade, and in patients with triple negative breast cancer, but not reaching significance level (p<0.1). We also found other well-known relationships such as a high correlation between ER and PR (p < 0.001), and that mass lesions are more likely to show washout DCE pattern (p<0.017).