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Abstract #0587

Dynamic Imaging of Dual Contrast-Enhancement Using a Combined MR-Optical Imaging System

Mehmet Burcin Unlu1, Yuting Lin1, Orhan Nalcioglu1, Gultekin Gulsen1

1John Tu & Thomas Yuen Center for Functional Onco-Imaging, University of California, Irvine, CA, USA

We measure the enhancement kinetics of an optical and an MR contrast agent in a small animal breast tumor model (R3230 ac) simultaneously using a combined magnetic resonance-diffuse optical tomographic imaging system. A mixture of a small molecular-weight MR contrast agent Gd-DTPA and a large molecular-weight optical contrast agent indocyanine green was administered intravenously for multimodal dynamic imaging.