Dynamic Imaging of Dual Contrast-Enhancement Using a Combined MR-Optical Imaging System

Mehmet Burcin Unlu¹, Yuting Lin¹, Orhan Nalcioglu¹, Gultekin Gulsen¹

We measure the enhancement kinetics of an optical and an MR contrast agent in a small animal breast tumor model (R3230 ac) simultaneously using a combined magnetic resonance-diffuse optical tomographic imaging system. A mixture of a small molecular-weight MR contrast agent Gd-DTPA and a large molecular-weight optical contrast agent indocyanine green was administered intravenously for multimodal dynamic imaging.