Abstract #0596

Direct Imaging of SPIOs in Mice Using Magnetic Particle Imaging: Instrument Construction and 3D Imaging

Patrick Goodwill¹, Greig Scott², Pascal Stang², Gary Chiray Lee¹, Doug Morris³, Steve Conolly⁴

¹Joint Graduate Group in Bioengineering, UC Berkeley / UCSF, Berkeley, CA, USA; ²Electrical Engineering, Stanford University; ³National Institutes of Health, Bethesda, MD, USA; ⁴Bioengineering, University of California, Berkeley, Berkeley, CA, USA

We have developed the first Magnetic Particle Imaging (MPI) scanner capable of imaging a whole mouse. The system directly detects the magnetization of Super-Paramagnetic Iron Oxide (SPIO) particles commonly used as MRI contrast agents with remarkable sensitivity and resolution over a 3cm field of view without requiring sample movement. Our system incorporates technical advances that enable small receive bandwidths at high frequencies, with a clear path towards body noise dominance.