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Abstract #0596

Direct Imaging of SPIOs in Mice Using Magnetic Particle Imaging: Instrument Construction and 3D Imaging

Patrick Goodwill1, Greig Scott2, Pascal Stang2, Gary Chiray Lee1, Doug Morris3, Steve Conolly4

1Joint Graduate Group in Bioengineering, UC Berkeley / UCSF, Berkeley, CA, USA; 2Electrical Engineering, Stanford University; 3National Institutes of Health, Bethesda, MD, USA; 4Bioengineering, University of California, Berkeley, Berkeley, CA, USA

We have developed the first Magnetic Particle Imaging (MPI) scanner capable of imaging a whole mouse. The system directly detects the magnetization of Super-Paramagnetic Iron Oxide (SPIO) particles commonly used as MRI contrast agents with remarkable sensitivity and resolution over a 3cm field of view without requiring sample movement. Our system incorporates technical advances that enable small receive bandwidths at high frequencies, with a clear path towards body noise dominance.