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Abstract #0604

Thrombus Development and Fragmentation in Rats Using Non-Enhanced MRI

Abdel Bidar1, Frank Risse1, Anna Ravnefjord2, Susanna Pehrsson2, Arno Nauerth3, Margareta Elg2, Paul D. Hockings1

1DECS Imaging, AstraZeneca, Molndal, Sweden; 2BioScience, AstraZeneca, Molndal, Sweden; 3Bruker BioSpin, Ettlingen, Germany

To our knowledge this is the first study to show the time course of thrombus formation over the first 4 days. Maximal average thrombus size was obtained 50 minutes after thrombus induction with no marked decrease over the following 4 days. Thrombus fragmentation was seen in several rats which potentially explains some of the variability seen in thrombosis models. An excellent correlation was found for MRI volume measurement and wet weight. MRI can follow thrombus formation, growth, fragmentation and dissolution in the same animal and thus drastically reduce the number of animals needed.