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Abstract #0621

Multi-Phase Pseudo-Continuous Arterial Spin Labeling (MP PCASL): Robust PCASL Method for CBF Quantification

Youngkyoo Jung1, Eric C. Wong1,2, Thomas T. Liu1

1Radiology, University of California, San Diego, San Diego, CA, USA; 2Psychiatry, University of California, San Diego, San Diego, CA, USA

The pseudo-continuous arterial spin labeling method for CBF quantification offers higher SNR and therefore the potential for improved quantification compared to pulsed ASL. The tagging efficiency of PCASL can be significantly modulated by both gradient imperfections and the off-resonance fields at the tagged vessels. We propose a novel PCASL method with multiple phase offsets which is less sensitive to these factors. Our result shows that the CBF measures obtained with the proposed method were more consistent with the reference CBF values obtained with FAIR and both conventional PCASL and MP PCASL provide higher SNR than the FAIR ASL method.