The Limbic System in Asperger Syndrome: A Preliminary Diffusion Tensor Imaging Tractography Study

Luca Pugliese^1,2, Michel Thiebaut de Scotten^1,2, Stephanie Ameis², Flavio Dell'Acqua^1,2, Eileen Daly¹, Declan Murphy¹, Marco Catani^1,2

It has been suggested that people with Autistic Spectrum Disorder (ASD) have altered development (and connectivity) of limbic circuits. However, direct evidence is lacking. We used DTI-tractography to compare, in vivo, tract-specific measurements along the principal limbic pathways between subjects with Asperger syndrome and healthy controls.