Nirmalya Ghosh1, Stephen Ashwal1, Andre Obenaus2
1Department of Pediatrics, Loma Linda University, Loma Linda, CA, USA; 2Department of Radiology and Radiation Medicine, Loma Linda University, Loma Linda, CA, USA
Manual quantification methods have hindered objective and rapid MRI analysis of neonatal hypoxic brain injury and its complex interactions with implanted therapeutic neuronal stem cells (NSCs). To extract such information to understand stem cell therapeutic activity, we need an automated MRI analysis method. Hierarchical Region Splitting (HRS) detects and quantifies lesion and NSCs and their internal compositions over time and space to quantify individual characteristics and interactions more objectively.