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Abstract #0671

Age and Gender Related Changes in DTI Metrics in Deep Grey Matter of Normal Human Brain

Deepa Pal1, Abhishek Yadav1, Ram K S Rathore2, Chandra Mohan Pandey3, Manoj Kumar1, Richa Trivedi1, Rakesh K. Gupta1

1Department of Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; 2Department of Mathematics and Statistics, Indian Institute of Technology, Kanpur, India; 3Department of Biostatistics, Sanjay Gandhi Post Graduate Institute of Medical Science, Lucknow, UP, India

Diffusion tensor imaging was performed on 125 healthy volunteers ranged from 10 days to 52 years. In which 50 subjects were female and rest of 75 were males. For the purpose of DTI quantitation region of interests (ROI)s were placed on deep grey nuclei (i.e. caudate nuclei, putamen and globus pallidus at the level of third ventricle) in all subjects. Increase in FA along with decrease in MD values was observed as a function of age in all of the deep grey nuclei. We observed higher FA values in all regions in males compared to females. Age related increase in FA values in grey matter suggest increased iron accumulation that occurs during the normal course of ageing. This normative data may help in early detection of neuronal degeneration associated with iron metabolism in future.