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Abstract #0700

Improved Arterial Spin Labeling After Myocardial Infarction in Mice Using Respiratory and Cardiac Gated Look-Locker Imaging with Fuzzy C-Means Clustering for T1 Estimation

Moriel H. Vandsburger1, Robert L. Janiczek1, Brent A. French1,2, Craig H. Meyer1, Christopher M. Kramer2,3, Frederick H. Epstein1,2

1Biomedical Engineering, University of Virginia, Charlottesville, VA, USA; 2Radiology, University of Virginia, Charlottesville, VA, USA; 3Medicine, University of Virginia, Charlottesville, VA, USA

Measurment of myocardial perfusion in mouse models of acute myocardial infarction (MI) by arterial spin labeling (ASL) has never been demonstrated. We developed a cardio-respiratory gated Look-Locker spiral ASL sequence which uses a fuzzy C-means (FCM) clustering algorithm to reconstruct ASL images and assign image inversion times (TIs). This reduced motion artifacts and improved quantification of perfusion. Mice were scanned at baseline (n=7) and one day after MI (n=6). Baseline perfusion of 3.5 0.3 (ml/gmin) rose after MI in the noninfarcted zone to 4.5 0.4 (ml/gmin) and dropped in the infarcted zone to 1.9 0.3 (ml/gmin).