Abstract #0733

Aricept Treatment Enhances Hippocampal Connectivity in Subjects with Mild Alzheimers Disease

Wenjun Li¹, Chunming Xie^1,2, Zhilin Wu¹, Jennifer Jones³, Piero Antuono³, Thomas McRae⁴, Shi-Jiang Li^1,5

¹Biophysics, Medical College of Wisconsin, Milwaukee, WI, USA; ²Neurology, School of Clinical Medicine, Southeaset University, Nanjing, Jiang Su, China; ³Neurology, Medical College of Wisconsin, Milwaukee, WI, USA; ⁴Pfizer, Inc.; ⁵Psychiatry, Medical College of Wisconsin, Milwaukee, WI, USA

Cholinergic inhibitor (Aricept) has proven to be successful in improving the cognitive function of adults with Alzheimers disease (AD). We hypothesize that since the cortical and hippocampal areas receive major cholinergic input from the basal forebrain nuclei, treatment with Aricept can improve the cholinergic activity of AD; it will improve connectivity of the hippocampus network.