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Abstract #0736

Tract-Based Spatial Statistics (TBSS) Study in Parkinsons Disease Identifies Focal Microstructural Abnormality

Martyn Ezra1, V Gontu2, Maryam Abaei1, Paul S. Morgan1, Nin Bajaj2, Dorothee P. Auer1

1Academic Radiology, University of Nottingham, Nottingham, UK; 2Neurology, Derby Royal Infirmary, Derby, UK

This study aimed to investigate microstructural abnormalities in Patients with Parkinsons Disease (PwPD). Tract Based Spatial Statistics (TBSS) analysis was performed on Diffusion Tensor Imaging (DTI) data for 26 PwPD and 16 matched controls. We demonstrated focal reduction in Fractional Anisotrophy in the Postural Instability Gait Difficulty (PIGD) subgroup in the left temporo-parietal white matter (WM). Posthoc region of interest (ROI) analysis confirmed a subgroup concordance. Location & subgroup concordance point towards an association with cognitive symptoms in PwPD.