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Abstract #0769

Molecular Pathobiology of Prostate Cancer

Angelo M. De Marzo1

1Johns Hopkins University, Baltimore, MD, USA

Prostatic adenocarcinoma represents the second leading cause of cancer death in American men. The recent application of molecular approaches to the study of prostate cancer has resulted in a rapid increase in the identification of somatic genome alterations as well as germline heritable risk factors in this disease. These findings are leading to a new understanding of the pathogenesis of prostate cancer and to the generation of new targets for diagnosis, prognosis, prediction of therapeutic response, and molecular imaging.