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Abstract #0790

Taurine- A Possible Biomarker in Urine of Urinary Bladder Cancer by 1H NMR Spectroscopy: A Pilot Study

Abhinav Arun Sonkar1, Shatakshi Srivastava2, Sudhir Singh1, Diwakar Dalela3, Satya Narayanan Sankhwar3, Apul Goel3, Raja Roy2

1Department of Surgery, CSM Medical University, Lucknow, Uttar Pradesh, India; 2Centre of Biomedical Magnetic Resonance, Sanjay Gandhi Post Graduate Institute, Lucknow, Uttar Pradesh, India; 3Department of Urology, CSM Medical University, Lucknow, Uttar Pradesh, India

The increase in rate of urinary bladder cancer has aroused the need for development of better treatment strategies and consequently, improved diagnostic techniques. The biomarker study of non-invasive body fluid as urine may provide, firstly, a better insight for metabolic processes occuring in pathological state and secondly, improved diagnosis. The altered concentrations of small metabolites viz.taurine, citrate and phenylalanine may provide a diagnostic measure for bladder cancer. Techniques like cytology apart from being invasive suffer from lower sensitivity. Therefore, 1H NMR spectroscopy has been employed for gathering information present in urine of bladder cancer patients, in form of small metabolites.