True MR Microscopy on a Clinical 7 Tesla Scanner: Application to Plaque Detection in Ex Vivo HCHWA-D Samples

Andrew Webb¹

A flexible MR microscopy probe has been constructed to obtain high resolution isotropic images on a clinical 7 tesla scanner of plaques in ex vivo brain specimens from individuals who have had hereditary cerebral haemorrhage with amyloidosis-Dutch type, a form of Alzheimers disease. Images acquired at a spatial resolution of 40 x 50 x 100 microns show individual iron-containing plaques, which both confirm previous results obtained at much poorer spatial resolution, but also add detailed information on the biodistribution of these plaques.