Abstract #0829

MRI Tissue Window Chamber System for Validation and Optimization of Dynamic Contrast Enhanced Tumor Imaging

Olivier Maciej Girard^1,2, Ahmet Erten^2,3, Mark Bydder¹, Milan T. Makale², David A. Cheresh², David Gilderdale⁴, Sadik Esener^2,3, Robert Frederick Mattrey^1,2

¹Department of Radiology, University of California, San Diego, CA, USA; ²Moores Cancer Center, University of California, San Diego, CA, USA; ³Electrical Engineering , University of California, San Diego, CA, USA; ⁴PulseTeq, UK

Magnetic Resonance Imaging (MRI) holds significant promise to achieve quantitative analysis of tumor vasculature. However with deep tumor MRI there is no means by which to validate in vivo methods and results, especially those of a dynamic nature. We report here on the design and fabrication of a MRI and light microscope compatible window chamber, and initial time course data following Gd injection. Such a system is a significant step toward validation of permeability measurement by MRI with the light microscope.