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Abstract #0831

An Oxygen Consuming Phantom for Simulating Oxygen Perfusion in Tissue Using 19F MRI Oximetry

Steven H. Baete1,2, Yves De Deene1,2

11Laboratory for Quantitative Nuclear Magnetic Resonance in Medicine and Biology, ECNURAD, Ghent University, Ghent, Oost-Vlaanderen, Belgium; 2Medisip-IBBT, Ghent University, Ghent, Oost-Vlaanderen, Belgium

Tumor hypoxia is well known to reduce cancer treatment efficacy. 19F MRI oximetry can be used to map oxygen concentrations in hypoxic tissue. However, validation of pO2-measurements in vivo is difficult. In this study, an oxygen consuming phantom simulating oxygen perfusion in tissue is presented. The phantom consists of a hemodialysis filter of which the outer compartment is filled with a gel containing viable yeast cells. pO2-images reveal oxygen consumption by the yeast after injection of a bolus of oxygen rich hexafluorobenzene in the fibers of the hemodialysis filter. The phantom can be used for validation of 19F MRI oximetry.