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Abstract #0834

Neural Precursor Migration Following Intracerebroventricular Delivery During the Chronic Phase of Experimental Allergic Encephalomyelitis Is Reduced as Compared to the Acute Phase

Naser Muja1,2, Mikhal Cohen3, Jiangyang Zhang1, Assaf A. Gilad1,2, Piotr Walczak1,2, Tamir Ben-Hur3, Jeff W.M. Bulte1,2

1Radiology, Divivsion of MR Research, Johns Hopkins University, Baltimore, MD, USA; 2Institute for Cell Engineering, Johns Hopkins University, Baltimore , MD, USA; 3Department of Neurology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

Using experimental autoimmune encephalomyelitis (EAE) as a mouse model for multiple sclerosis, we used serial MR imaging of Feridex-labeled neural precursor cells (NPCs) to detect potential differences in the migratory response of ICV-transplanted NPCs between the acute inflammatory or the chronic demyelinated phase of the disease. We found that cell movements are determined by the phase of EAE, with a characteristic radial migration pattern of cells moving out from the ventricular spaces into and around blood vessels within the somatosensory cortex during the acute but not the chronic phase.