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Abstract #0837

Diffusion Anisotropy Correlates Compound Action Potential in the Optic Nerve from Mice of Retina Ischemia

Qing Wang1, Roman Vlkolinsky2, Sheng-Kwei Song3, Andre Obenaus4

1Washington University, Saint Louis, MO, USA; 2Loma Linda University School of Medicine; 3Washington University School of Medicine; 4Loma Linda Unieristy School of Medicine, Loma Linda, CA, USA

The compound action potential (CAP) amplitude was measured by the extracellular recording ex vivo on optic nerves from the control, and retinal ischemia mice at 3 and 7 days after injury. The axonal and myelin integrity of optic nerve from control and retinal ischemic mice as evaluated using diffusion tensor imaging (DTI). The correlation between DTI and CAP was established. The results suggest that the decreased diffusion anisotropy may reflect the function of optic nerve after retinal ischemia better despite the presence of axonal injury may be responsible for the long term disability of visual function. And the overall functional assessment would be best to be evaluated by diffusion anisotropy than axial or radial diffusivity alone.