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Abstract #0865

The Role of Intravascular Effects in Phase Contrast Between Gray and White Matter

Natalia Petridou1, Samuel J. Wharton1, Ashley Lotfipour1, Penny Gowland1, Richard Bowtell1

1SPMMRC, University of Nottingham, Nottingham, UK

MR phase images exhibit exceptional contrast between Gray and White Matter. Here we examine the contribution of blood-related sources to this contrast by modulating the blood susceptibility with a gadolinium-based contrast agent during time-series phase imaging. We found that the GM/WM phase difference increased during the bolus pass but returned approximately to pre-contrast values after recirculation, while the GM/vasculature phase difference remained enhanced. Thus the significantly elevated susceptibility of blood due to the steady-state concentration of gadolinium had no significant effect on the GM/WM susceptibility difference, indicating that the latter is not explained by deoxyhaemoglobin in blood.