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Abstract #0877

About the Origins of Enhanced Visualization of Amyloid Plaques on APP/PS1 Mouse Brain Using GdDOTA Passive Staining

Benjamin Marty1, Julien Flament1, Julien Valette1, Fawzi Boumezbeur1, Marc Dhenain1, Franck Lethimonnier1, Sbastien Mriaux1

1Neurospin, I2BM, Commisariat l'Energie Atomique, Gif-sur-Yvette, France

The present study shows the interest of passive staining and T2* weighted images to detect amyloid plaques on a APP/PS1 mouse brain. It also focus on the diffusion of contrast agent during this experiment and the consequences on the contrast of images. It shows that an important contrast in proton density appears added to the existent T2* contrast.