Ching-Tang Chen1, Chia-Hao Su1, Yi-Chien Lu1, Ang Yuan2, Jyh-Horng Chen1
1Interdisciplinary MRI/MRS Lab, Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan, Taiwan; 2Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, Taiwan
We have demonstrated that Fe3O4@anti-EGFR antibody nanoparticles were capable of probing NSCLC cells in vitro and in vivo. Furthermore, its large different expression between NSCLC cells and monocyte provide nanoparticles higher chance to target the extracellular domain of EGF receptors in tumor cells. And we also have investigated the biodistribution, and kinetics of the nanoparticles. By recombining the desired targeting moiety and various functional nanoparticles through bioconjugation, this modularly designed platform has the capability of enhancing the efficiency of targeted diagnosis and therapies for a wide spectrum of biomedical applications.
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