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Abstract #0882

Contrast Enhanced MR Imaging of Liver Tumors in HBV Transgenic Mice

Vito Lorusso1, Luigi Miragoli1, Linda Chaabane2, Achille Iolascon3, Daniela Spano3, Vittorio Di Maso4, Claudio Tiribelli4, Fulvio Uggeri1

1Bracco Research Centre, Bracco Imaging spa, Colleretto Giacosa, Torino, Italy; 2RBM-Merk-Serono, Colleretto Giacosa, Torino, Italy; 3CEINGE, Napoli, Italy; 4Centro Studi Fegato, Trieste, Italy

In the HBx transgenic mouse model chronic hepatocellular injury and inflammation lead to regenerative hyperplasia and to the development of hepatocellular carcinoma thereby resembling many of the physiopathological events that occur prior to the development of HCC in chronic HBV infection in humans.