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Abstract #0886

Detection and Characterization of Europium Based PARACEST Contrast Agents

Heather H. Cornnell1, Arthur S. Edison2,3, Glenn A. Walter3,4

1Biomedical Engineering, University of Florida, Gainesville, FL, USA; 2Biochemistry & Molecular Biology, University of Florida, Gainesville, FL, USA; 3National High Magnetic Field Laboratory, University of Florida, FL, USA; 44Physiology and Functional Genomics, University of Florida, Gainesville, FL, USA

Paramagnetic Chemical Exchange Saturation Transfer (PARACEST) utilizes an RF pulse to saturate a small pool of bound protons at the chemical shift induced by the paramagnetic lanthanide complexes. Exchange between this saturated proton pool and free protons in bulk water results in decreased signal from bulk water. Sensitivity to small concentrations of PARACEST agent would be useful to increase the potential for this mode of contrast generation. This abstract investigates the detection of a europium based PARACEST agent from 100mM down to 0.4mM. The results demonstrate contrast generation at 14.6T for various pH’s and temperatures.