Xianfeng Shi1, Xin Liu2, Xueming Wu3, Zhengrong Lu4, Kevin Li5, EunKee Jeong6
1Department of Physics, University of utah, Salt Lake City, UT, USA; 2Department of physics, University of Utah, Salt Lake City, UT, USA; 3Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, USA; 4Department of Pharmaceutics and Pharmaceutical Chemistry, University of utah, Salt Lake City, UT, USA; 5Division of Pharmaceutical Sciences, University of Cincinnati, Salt Lake City, UT, USA; 6Department of Radiology, University of utah, Salt Lake City, UT, USA
Recent advances in drug discovery have led to the development of effective therapeutic agents for the treatment of posterior eye diseases. However, drug delivery to the posterior eye remains a challenge and intravitreal injection continues to be the most common method in ocular drug delivery to the back of the eye. The use of MRI to study the distribution of biodegradable synthetic polymer in the eye would help us understand the ocular drug-delivery mechanism and clearance after intravitreal injection. In this report, we present an MRI study of polymerized biodegradable drug surrogate conjugated with Gd-chelate that was injected into the rabbit eye.
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