Meeting Banner
Abstract #0914

Coupling 18F-Deoxyglucose PET Imaging and MRS at 14T of the in Vivo GLUT8 Knockout Mouse Brain

Carole Lynn Poitry-Yamate1, Bernard Lanz1, Hongxia Lei1, Frederic Prietner2, Stephane Germain1, Bernard Thorens2, Rolf Gruetter1,3

1IPMC, EPFL, Lausanne, Vaud, Switzerland; 2University of Lausanne, Lausanne, Vaud, Switzerland; 3Radiology, University of Lausanne and Geneva, Switzerland

We have undertaken the first combined study of 18FDG PET imaging and NMR spectroscopy of GLUT8 KO mice in vivo. Accumulated, intracellular 18FDG-6-phosphate was increased in functionally distinct brain regions of GLUT8 KO mice relative to WT mice, while regional brain glucose concentrations remained unchanged. Given that GLUT8 is localized to an intracellular storage site, these findings were unexpected. Possibilities to account for these observations are presented.