Abstract #0914

Coupling 18F-Deoxyglucose PET Imaging and MRS at 14T of the in Vivo GLUT8 Knockout Mouse Brain

Carole Lynn Poitry-Yamate¹, Bernard Lanz¹, Hongxia Lei¹, Frederic Prietner², Stephane Germain¹, Bernard Thorens², Rolf Gruetter^1,3

¹IPMC, EPFL, Lausanne, Vaud, Switzerland; ²University of Lausanne, Lausanne, Vaud, Switzerland; ³Radiology, University of Lausanne and Geneva, Switzerland

We have undertaken the first combined study of ¹⁸FDG PET imaging and NMR spectroscopy of GLUT8 KO mice in vivo. Accumulated, intracellular ¹⁸FDG-6-phosphate was increased in functionally distinct brain regions of GLUT8 KO mice relative to WT mice, while regional brain glucose concentrations remained unchanged. Given that GLUT8 is localized to an intracellular storage site, these findings were unexpected. Possibilities to account for these observations are presented.