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Abstract #0946

Histological Validation of Hemorrhage and Temporal Blood Transformation Detected by Susceptibility Weighted Imaging in Traumatic Brain Injury

Zhifeng Kou1, Yimin Shen1, Nirsine Zakaria2, Srini Kallak3, John Cavanaugh3, E Mark Haacke1

1Radiology, Wayne State University, Detroit, MI, USA; 2Biomedical Engineering, Wayne State University, Detroit, USA; 3Biomedical Engineering, Wayne State University, Detroit, MI, USA

Susceptibility weighted imaging (SWI) has demonstrated to be extremely sensitive to microhemorrhages after trauma. However, no data has been reported to validate SWI findings as blood products. In this study, histological validation (Prussian Blue staining) in a brain injury animal model was performed to prove that microhemorrhages detected by SWI in traumatic brain injury do represent blood products. SWI also demonstrated a temporal pattern of hemorrhagic blood transformation in brain trauma. Our data suggested that an appropriate timing point is critical to acutely detect blood product after trauma.