Abstract #0979

Predicting Response to Anti-Angiogenic Chemotherapy in Patients with High-Grade Glioblastomas Using MR Perfusion Imaging

Rahul Sawlani^1,2, Jeffrey Raizer, MD³, Sandra W. Horowitz¹, Wanyong Shin^1,2, Sean A. Grimm³, James P. Chandler⁴, Robert Levy⁴, Christopher C. Getch⁴, Maulin Shah^1,2, Timothy J. Carroll^1,2

¹Radiology, Northwestern University, Chicago, IL, USA; ²Biomedical Engineering, Northwestern University, Evanston, IL, USA; ³Neurology, Northwestern University, Chicago, IL, USA; ⁴Neurosurgery, Northwestern University, Chicago, IL, USA

Using MR perfusion imaging, the response to anti-angiogenic chemotherapy can be predicted for individual patients. In this study, we evaluated twelve patients with high-grade GBMs on a trial of Bevacizumab. For each patient, change in perfusion from before to after start of treatment was compared to the number of days to tumor progression.