Jannie Petra Wijnen1, Miriam W. Lagemaat2, Patrick Krooshof3, Albert J.S. Idema4, Geert J. Postma3, Lutgarde C.M. Buydens3, Tom W.J. Scheenen1, Arend Heerschap1
1Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands; 2Radiology, Radboud Universtiy Nijmegen Medical Centre, Nijmegen, Netherlands; 3Analytical Chemistry, Radboud University Nijmegen, Nijmegen, Netherlands; 4Neurosurgery, Radboud Universtiy Nijmegen Medical Centre, Nijmegen, Netherlands
In this study we investigated the presence of possible differences in metabolite levels in glioblastoma multiforme and metastase as observed by 1H Magnetic Resonance Spectroscopic Imaging. Typical regions in and around the tumor of patients with a glioblastoma multiforme (14) and patients with a metastasis (9) were examined with a short echo time semi-LASER sequence at 3T. Significant differences between these tumor types were observed in relative mI+Gly levels and relative Cho levels in the peritumoral T2 hyperintense regions pointing to differences in intersitial pressure and tumor infiltration.