Abstract #0987

Short Echo Time 1H Magnetic Resonance Spectroscopic Imaging in the Differentiation of High Grade Gliomas and Metastases in the Human Brain.

Jannie Petra Wijnen¹, Miriam W. Lagemaat², Patrick Krooshof³, Albert J.S. Idema⁴, Geert J. Postma³, Lutgarde C.M. Buydens³, Tom W.J. Scheenen¹, Arend Heerschap¹

¹Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands; ²Radiology, Radboud Universtiy Nijmegen Medical Centre, Nijmegen, Netherlands; ³Analytical Chemistry, Radboud University Nijmegen, Nijmegen, Netherlands; ⁴Neurosurgery, Radboud Universtiy Nijmegen Medical Centre, Nijmegen, Netherlands

In this study we investigated the presence of possible differences in metabolite levels in glioblastoma multiforme and metastase as observed by ¹H Magnetic Resonance Spectroscopic Imaging. Typical regions in and around the tumor of patients with a glioblastoma multiforme (14) and patients with a metastasis (9) were examined with a short echo time semi-LASER sequence at 3T. Significant differences between these tumor types were observed in relative mI+Gly levels and relative Cho levels in the peritumoral T2 hyperintense regions pointing to differences in intersitial pressure and tumor infiltration.