Abstract #0990

Perilesional Area of Brain Tumors: A Longitudinal Diffusion Tensor Imaging Study

Kun-Hsien Chou¹, Hsuan-Hui Wang², Wan-You Guo³, Ming-Tak Ho⁴, Ming-Hsiung Chen⁵, Woei-Chyn Chu¹, Ching-Po Lin^2,6

¹Institute of Biomedical Engineering, National Yang Ming University, Taipei, Taiwan; ²Institute of Biomedical imaging and Radiological Sciences, National Yang Ming University, Taipei, Taiwan; ³Division of Neuroradiology, Taipei Veterans General Hospital, Taipei, Taiwan; ⁴Department of Pathology, Taipei Veterans General Hospital, Taipei, Taiwan; ⁵Institute of Neurological Neurosurgery, Taipei Veterans General Hospital, Taipei, Taiwan; ⁶Institute of Neuroscience, National Yang Ming University, Taipei, Taiwan

Peritumoral signal abnormalities (PSA) of brain tumors contain varieties of tissues, and are categorized mainly to abnormal protons (vasogenic edema, gliosis) and/or tumor infiltration. In clinical experience, T2-weighted MR images are usually used to identify PSA in patients with tumors, even though the two types of signal abnormalities can still hardly be distinguished effectively up to date. In an attempt to circumvent this problem, a novel method was proposed and DTI was applied to differentiate the complex contents of PSA by reversibility. Differentiating tissue contents of PSA may facilitate tumoral delineation and therefore change the therapeutic strategy.