Yan Li1, Janine Lupo1, Wei Bian1, Jason C. Crane1, Soonmee Cha1, Susan Chang2, Sarah Nelson1,3
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA; 2Department of Neurological Surgery, University of California, San Francisco, CA, USA; 3Department of Bioengineering, University of California, San Francisco, CA, USA
Glioblastoma Multiforme (GBM) is the most common and the most malignant type of primary brain tumor, resulting in a median survival of approximately one year. Our study of 30 patients with GBM indicated that both the extent of resection and response to therapy were significantly associated with survival. Areas with a relatively large region having breakdown of the BBB, restricted diffusion or large CBV at pre-RT had shorter TTP. There was a relatively large increase in the nADC within the T2ALL lesion for the patients who progressed early compared to patients who progressed at a later time. The increase in anatomic volumes and values of nADC are significantly correlated with progression.