Xiang Liu1, Wei Tian2, Sven Ekholm1
1Department of Radiology, University of Rochester Medical Center, Rochester, NY, USA; 2Department of Radiology, ; University of Rochester Medical Center, Rochester, NY, USA
The pre-operative grading of non-enhancing gliomas is difficult on conventional MRI and very important as up to 40% could be malignant. The purpose of this study was to evaluate if PWI and DTI could improve the grading accuracy. 39 patients with pathology confirmed non-enhancing supratentorial gliomas were included. The maximal and the mean FA showed significant difference between groups, accompanying with sensitivity and specificity of 90% based on threshold of 0.243 and 0.141 respectively. However, there was no significant difference of maximal rCBV and mean ADC. The maximal and average FA are better surrogate markers in differentiating non-enhancing supratentorial gliomas.