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Abstract #1000

Improved RCBV Calculation with Leakage Correction and First Pass Extraction

Xintao Hu1,2, Kelvin Wong1,3, Pamela New4, Stephen Wong1,3

1Department of Radiology, The Methodist Hospital Research Institute, Houston, TX, USA; 2Department of Automation, Northwestern Polytechnical University, Xi'an, ShaanXi, China; 3Department of Radiology, Weill Medical College of Cornell University, New York, NY, USA; 4Department of Neurosurgery, The Methodist Hospital, Houston, TX, USA

Contrast agent leaking into extravascular space leads to inaccurate rCBV measurement using DSC-PWI. The errors might be magnified with the accumulated effect during blood recirculation phase. We introduced a method to extract the first pass of contrast agent concentration time curve by decomposing the tissue residue function R(t) into first pass and recirculation. R(t) was deduced from deconvolution using least-absolute-deviation regularization, which has been proved to preserve the shape of R(t) while reducing baseline oscillation. The proposed method was evaluated in CBV calculation in a longitudinal follow-up study of GBM patients undergoing gene therapy.