Abstract #1002

4 Year Longitudinal MRI Follow-Up and 1H Single Voxel MRS in 22 Patients with Oligodendroglial Tumors or Gliomatosis Treated with Temodal

Jean-Marc Constans^1,2, Gabriela Hossu¹, Franois Kauffmann³, Weibei Dou⁴, Su Ruan⁵, Franois Rioult⁶, Jean-Michel Derlon⁷, Emanuelle Lechapt Zalcman^8,9, Myriam Bernaudin⁹, Franoise Chapon⁸, Samuel Valable⁹, Patrick Courthoux¹, Jean-Sebastien Guillamo^9,10

¹MRI Unit, Caen University Hospital, Caen, Normandy, France; ²CERVOxy and UMR 6232 CI-NAPS , Cyceron, Caen, Normandy, France; ³Mathematics LMNO CNRS UMR 6139, Caen University, Caen, Normandy, France; ⁴Tsinghua University, Beijing, China; ⁵CReSTIC EA 3804, IUT Troyes, Troyes, France; ⁶CNRS UMR 6072, GREYC, Caen, Normandy, France; ⁷Neurosurgery, Caen University Hospital, Caen, Normandy, France; ⁸Pathology, Caen University Hospital, Caen, Normandy, France; ⁹CERVOxy and UMR 6232 CI-NAPS, Cyceron, Caen, Normandy, France; ¹⁰Neurosurgery and Neurology, Caen University Hospital, Caen, Normandy, France

MRS with Cho/Cr and NAA/Cr ratios, could be more sensitive than MRI and, could be predictive of worsening. These spectroscopic and metabolic changes occur well before clinical deterioration and just before improvement. There is a large variability, but repetition and modelization of spectroscopic measurements during longitudinal follow-up could allow us to diminish it and to improve prognostic evaluation.