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Abstract #1002

4 Year Longitudinal MRI Follow-Up and 1H Single Voxel MRS in 22 Patients with Oligodendroglial Tumors or Gliomatosis Treated with Temodal

Jean-Marc Constans1,2, Gabriela Hossu1, Franois Kauffmann3, Weibei Dou4, Su Ruan5, Franois Rioult6, Jean-Michel Derlon7, Emanuelle Lechapt Zalcman8,9, Myriam Bernaudin9, Franoise Chapon8, Samuel Valable9, Patrick Courthoux1, Jean-Sebastien Guillamo9,10

1MRI Unit, Caen University Hospital, Caen, Normandy, France; 2CERVOxy and UMR 6232 CI-NAPS , Cyceron, Caen, Normandy, France; 3Mathematics LMNO CNRS UMR 6139, Caen University, Caen, Normandy, France; 4Tsinghua University, Beijing, China; 5CReSTIC EA 3804, IUT Troyes, Troyes, France; 6CNRS UMR 6072, GREYC, Caen, Normandy, France; 7Neurosurgery, Caen University Hospital, Caen, Normandy, France; 8Pathology, Caen University Hospital, Caen, Normandy, France; 9CERVOxy and UMR 6232 CI-NAPS, Cyceron, Caen, Normandy, France; 10Neurosurgery and Neurology, Caen University Hospital, Caen, Normandy, France

MRS with Cho/Cr and NAA/Cr ratios, could be more sensitive than MRI and, could be predictive of worsening. These spectroscopic and metabolic changes occur well before clinical deterioration and just before improvement. There is a large variability, but repetition and modelization of spectroscopic measurements during longitudinal follow-up could allow us to diminish it and to improve prognostic evaluation.