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Abstract #1021

Seizures Induced by Chronic Pentylenetetrazol Treatment Result in Progressive Neuronal Injuries in Rat Hippocampus: An in Vivo 1H MRS Study

Fang Fang1, Hao Lei1

1Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, Hubei, China

In this study, in vivo 1H MRS was used to measure the NAA/tCr ratio in the hippocampus of rats treated with pentylenetetrazol (PTZ) for 28 days. The results showed that the PTZ-treated rats had significantly lower hippocampal NAA/tCr ratio than the control animals. The extents of neuronal injuries in the hippocampus of PTZ-treated rats appeared to be dependent on the history of the seizures occurred during the course of epileptogenesis.