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Abstract #1023

Tracking the Limbic-Frontal Glutamate System Associated with Aged Emotion Regulation

Wei Chen1, Elizabeth Rouse2, David Olson2, Jean A. King

1 Center for Comparative Neuroimaging,Psychiatry, University of Massachusetts Medical School, Worcester, MA, USA; 2Brain Imaging Center, McLean Hospital,Harvard Medical School, Belmont, MA, USA

Alternatively, neuronal loss or dysfunction associated with older age may be the result of mechanisms that affect all cells of the body. Evidence of frontal involvement in the regulation of emotion is further supported by imagining studies. The current study was designed to use functional Magnetic Resonance Imaging (fMRI) and proton MR spectroscopic imaging (1H-MRSI) techniques to explore the neurochemical mechanisms related to the brain functional changes in fear response in aging rats. A fuller understanding of the role of limbic-frontal glutamate systems in fear and fear learning may suggest novel pharmacological approaches to the treatment of clinical anxiety disorders.