Abstract #1029

Deep Thiopental Anesthesia Alters Glucose Homeostasis But Not the Neurochemical Profile in Rat Cortex

Hongxia Lei^1,2, Joao MN Duarte^1,2, Vladmir Mlynarik¹, Agathe Python¹, rolf Gruetter^1,3

¹EPFL, Lausanne, Vaud, Switzerland; ²UNIL, Lausanne, Vaud, Switzerland; ³UNIGE, Geneva, Switzerland

Previous studies suggested pentobarbital affected brain glucose homeostasis by varying glucose transport at blood-brain barrier and regional consumption. However, the drug carriers in pentobarbital, alcohols have been found contributing to the previously observed effect. In this study, by eliminating potential influents, we studied the effect of deep thiopental on cortex glucose transport kinetics and resulted in the elevated glucose uptake but no significant changes in other metabolites.