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Abstract #1031

In Vivo Proton MRS Changes in Geriatric Rhesus Monkey Brain: Similarities to Human Alzheimer's Disease

RoseAnn Blenman-Abange1, Richard Baumgartner2, Marie Holahan1, Jacquelynn Cook1, Richard Hargreaves1, Donald Williams1

1Merck & Co Inc., West Point, PA, USA; 2Merck & Co Inc., Rahway, NJ, USA

Proton MRS in the posterior cingulate of geriatric (≥24 years) Rhesus monkeys revealed decreased NAA/tCr, tCho/tCr and Glu/tCr and increased mI/tCr as compared to young adult monkeys (≤15 years). Since geriatric Rhesus have been shown to have brain and behavioral abnormalities similar to AD patients, our hypothesis was that they would have altered biochemical profiles similar to those observed in human AD. Results also showed that NAA/tCr, mI/tCr, tCho/tCr and Glu/tCr are highly correlated with age and that a panel of these 4 human AD biomarkers could be used to classify the young versus geriatrics with 99% accuracy.