Abstract #1035

Metabolic Changes Detected by in Vivo Proton Magnetic Resonance Spectroscopy in the Striatum of Rats Treated with Alteration of Dietary Sulfur Amino Acids Content

Li Wei¹, Youngjia Park², Dean P. Jones², Xiaoping Hu¹

¹Department of Biomedical Engineering and Biomedical Imaging Technology Center, Emory University, Atlanta, GA, USA; ²Department of Medicine and Center for Clinical and Molicular Nutrition, Emory University, Atlanta, GA, USA

Sulfur amino acids (SAA) play a central role in many diverse functions. SAA deficiency could induce complex metabolism perturbation. The specific effect of deficient dietary SAA content on brain is unknown. In vivo 1H MRS was used to monitor the changes in the level of metabolites in the striatum of rats through longitudinal experiments under the alteration of dietary SAA content. The result shows the concentration of Glx and Tau decreased significantly in the striatum of the rats fed SAA dificient diet and went back to the initial values after the follow-up treatment of SAA containing diet.