Abstract #1046

Concentration Changes of Vitamin C and GSH in the Human Brain as Function of Age

Uzay Emrah Emir¹, Susan Raatz², Carolyn Torkelson², Tonya White², Susuan McPherson², Pierre-Gilles Henry², Melissa Terpstra²

¹University of Minnesota , Minneapolis, MN , USA; ²University of Minnesota, Minneapolis, MN, USA

Vitamin C (Asc) and glutathione (GSH) are the most concentrated chemical antioxidants in the central nervous system. These anti-oxidant concentrations may reflect the pathogenesis of progressive neurodegenerative disorders, such as Alzheimers and Parkinsons disease, as well as cognitive decline.Double editing with (DEW) MEGA PRESS at high field has enabled noninvasive detection of these compounds in the human brain.This abstract presents preliminary findings on [Asc] and [GSH] as a function of age