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Abstract #1046

Concentration Changes of Vitamin C and GSH in the Human Brain as Function of Age

Uzay Emrah Emir1, Susan Raatz2, Carolyn Torkelson2, Tonya White2, Susuan McPherson2, Pierre-Gilles Henry2, Melissa Terpstra2

1University of Minnesota , Minneapolis, MN , USA; 2University of Minnesota, Minneapolis, MN, USA

Vitamin C (Asc) and glutathione (GSH) are the most concentrated chemical antioxidants in the central nervous system. These anti-oxidant concentrations may reflect the pathogenesis of progressive neurodegenerative disorders, such as Alzheimers and Parkinsons disease, as well as cognitive decline.Double editing with (DEW) MEGA PRESS at high field has enabled noninvasive detection of these compounds in the human brain.This abstract presents preliminary findings on [Asc] and [GSH] as a function of age