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Abstract #1058

Temporal Progression of Thalamic Plaques in Alzheimers Disease Transgenic Mice (TAS10, TPM, TASTPM) Comparison of MRI and CT

Andreas Pohlmann1, Fatima Alarakhia2, Brian P. Hayes3, Victor Musoko4, Marion J. Perren5, D Ceri Davies2, Michael F. James4

1Academic DPU, GlaxoSmithKline R&D Ltd, Cambridge, UK; 2Imperial College London, London, UK; 3Respiratory CEDD, GlaxoSmithKline R&D Ltd, Stevenage, UK; 4Immuno-Inflammation CEDD, GlaxoSmithKline R&D Ltd, Harlow, UK; 5Neuroscience CEDD, GlaxoSmithKline R&D Ltd, Harlow, UK

In Alzheimers disease transgenic mice a co-accumulation of calcium and ferrous iron in some thalamic amyloid plaques has been demonstrated, which co-localise with T2* hypointensities (THIs). We studied THI development with age and its correlation with calcium deposition using MRI and CT. The age-related growth of THIs differed significantly between genotypes but followed a similar trend in MRI and CT. THI volumes in CT and MRI correlated well and all but very small THIs were visualised by CT. Further characterization of THIs is necessary, but these findings may shed light on the pathogenesis of Alzheimers disease.