Meeting Banner
Abstract #1063

Progressive Neuroanatomical Changes in the YAC128 Mouse Model of Huntingtons Disease

Jason Philipp Lerch1, Jeffrey B. Carroll2, Matthijs van Eede1, Michael R. Hayden2, R. Mark Henkelman1

1Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada; 2Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada

We investigated the YAC128 mouse model of Huntington's Disease at 8 and 12 months of age using high-resolution MRI and found progressive atrophy in the striatum. The sensorimotor cortex, on the other hand, was thicker in YAC128 mice at 8 months of age but thinner than wild-type controls at 12 months, suggesting a potential compensatory mechanism in early stages of the disease.