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Abstract #1065

Intracellular PH Is a Promising Biomarker of Early Neurodegeneration, as Shown by 31P MRS in a 3-NP Rodent Model of Huntington's Disease

Myriam Marianne Chaumeil1,2, Celine Baligand3, Emmanuel Brouillet2, Philippe Hantraye2, Pierre Carlier3, Vincent Lebon1,2

1CEA-NeuroSpin, Gif-Sur-Yvette, France; 2CEA-MIRCen, Fontenay-aux-roses, France; 3Association Institut de Myologie, Paris, France

To investigate whether cerebral pH can serve as an early biomarker of neurodegeneration, we conducted a study on a rat model of Huntingtons disease (n=5, chronic intoxication using 3-NP). Cerebral pH was measured at D0, D1, D3 and D5 post-intoxication using a 31P-PRESS sequence. T2-weighted imaging was performed to detect cerebral lesions. This study shows a significant increase in cerebral pH before the onset of striatal lesions (pHD0=7.080.03 vs. pHD3=7.170.02). Furthermore, pH variations are shown to correlate with SDH inhibition (p<0.05). Consequently, cerebral pH appears to be a relevant early biomarker of neurodegeneration, reflecting precocious metabolic changes.