Myriam Marianne Chaumeil1,2, Celine Baligand3, Emmanuel Brouillet2, Philippe Hantraye2, Pierre Carlier3, Vincent Lebon1,2
1CEA-NeuroSpin, Gif-Sur-Yvette, France; 2CEA-MIRCen, Fontenay-aux-roses, France; 3Association Institut de Myologie, Paris, France
To investigate whether cerebral pH can serve as an early biomarker of neurodegeneration, we conducted a study on a rat model of Huntingtons disease (n=5, chronic intoxication using 3-NP). Cerebral pH was measured at D0, D1, D3 and D5 post-intoxication using a 31P-PRESS sequence. T2-weighted imaging was performed to detect cerebral lesions. This study shows a significant increase in cerebral pH before the onset of striatal lesions (pHD0=7.080.03 vs. pHD3=7.170.02). Furthermore, pH variations are shown to correlate with SDH inhibition (p<0.05). Consequently, cerebral pH appears to be a relevant early biomarker of neurodegeneration, reflecting precocious metabolic changes.