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Abstract #1073

Diffusion Tensor Imaging of Rat Model of Obsessive-Compulsive Disorder

Michael Dagan1, Oded Klavir2, Lior Brimberg2, Daphna Joel2, Yaniv Assaf1

1Department of Neurobiology, Tel Aviv University, Tel Aviv, Israel; 2Department of Psychology, Tel Aviv University, Tel Aviv, Israel

The localization of cognitive domains can be achieved by functional imaging modalities. It was recently shown that voxel-wise correlation between diffusion tensor imaging (DTI) indices and various behavioral measures allows brain localization of cognitive performance. In the present study we localized the behavioral manifestation of the signal attenuation (SA) rat model of obsessive-compulsive disorder (OCD) using DTI. It was found the FA and ADC reduces in many areas of the limbic system (mainly the hippocampus) as well as in the ventral striatum. These results suggest the behavior-DTI correlation may be used for characterization of plasticity induced morphological tissue changes.