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Abstract #1076

Long Term Effects of Recurrent Hyperglycemia on Hippocampal Neurochemistry in Developing Rats

Ivan Tkac1, Kathleen Ennis2, Raghavendra Rao2

1Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA; 2Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA

In vivo 1H NMR spectroscopy at 9.4T was used to investigate long-term effect of the recurrent hyperglycemia on the developing brain. Hyperglycemia of graded severity was induced in rat pups from postnatal day (P)3 to P12 and the spectroscopic data were collected on P30. Changes in Asc, Glu, PE and Tau indicated long-term alternation in hippocampal neurochemical profile. These finding imply that recurrent HG may have a role in the cognitive deficits common in preterm infants.