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Abstract #1078

S. Aureus Abscess Development in a Murine Model Measured Using MR Relaxometry and Diffusion Tensor Imaging

Michael Douglas Boska1, Mariano Uberti1, Amy Aldrich2, Erin McIntyre1, Tammy Kielian2

1Radiology, University of Nebraska Medical Center, Omaha, NE, USA; 2Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA

This murine model of bacterial brain abscess has been used extensively for studying the molecular and cellular events accompanying disease progression. This work extends prior studies by using quantitative MRI to characterize lesion development. Initial results demonstrate high T1 three days after infection in both the lesion and the surrounding tissue shown to be composed of activated macrophages/microglia. Day 7 shows the initial formation of the abscess wall as an area of low T1 and high FA which progresses to a more organized lesion and wall, reflected as decreasing T1, decreasing Dav, and increasing FA.