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Abstract #1084

Effect of Long-Term Caffeine Consumption on Glucose Transport and Osmolarity Alterations in the Hippocampus of STZ-Induced and Goto-Kakizaki Diabetic Rats: in Vivo1H MRS Study at 9.4 T

João M. N. Duarte1,2, Rui A. Carvalho2, Rodrigo A. Cunha2, Rolf Gruetter1,3

1LIFMET - CIBM, EPFL, Lausanne, Vaud, Switzerland; 2Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; 3Departments of Radiology, Universities of Lausanne and Geneva, Switzerland

Diabetes may affect the morphology and plasticity of the hippocampus, leading to cognitive impairment. We now studied alterations of metabolism in the hippocampus of diabetic rats and the protective effect of caffeine consumption.